Punishment diminishes the benefits of network reciprocity in social dilemma experiments

Network reciprocity has been widely advertised in theoretical studies as one of the basic cooperation-promoting mechanisms, but experimental evidence favoring this type of reciprocity was published only recently. When organized in an unchanging network of social contacts, human subjects cooperate provided the following strict condition is satisfied: The benefit of cooperation must outweigh the total cost of cooperating with all neighbors. In an attempt to relax this condition, we perform social dilemma experiments wherein network reciprocity is aided with another theoretically hypothesized cooperation-promoting mechanism—costly punishment. The results reveal how networks promote and stabilize cooperation. This stabilizing effect is stronger in a smaller-size neighborhood, as expected from theory and experiments. Contrary to expectations, punishment diminishes the benefits of network reciprocity by lowering assortment, payoff per round, and award for cooperative behavior. This diminishing effect is stronger in a larger-size neighborhood. An immediate implication is that the psychological effects of enduring punishment override the rational response anticipated in quantitative models of cooperation in networks.We thank J. H. Lee for useful discussions. M.J. and Z.W. were, respectively, supported by the Research Grant Program of Inamori Foundation and the Chinese Young 1000 Talents Plan. B.P. received support from the Slovenian Research Agency (ARRS) and the Croatian Science Foundation through Projects J5-8236 and 5349, respectively. S.H. thanks the Israel-Italian collaborative project Network Cyber Security (NECST), Israel Science Foundation, Office of Naval Research (ONR), Japan Science Foundation, and the US-Israel Binational Science Foundation and the US National Science Foundation (BSF-NSF) for financial support. The Boston University Center for Polymer Studies is supported by NSF Grants PHY-1505000, CMMI-1125290, and CHE-1213217, by Defense Threat Reduction Agency (DTRA) Grant HDTRA1-14-1-0017, and by Department of Energy (DOE) Contract DE-AC07-05Id14517. (Inamori Foundation; Chinese Young 1000 Talents Plan; J5-8236 - Slovenian Research Agency (ARRS); 5349 - Croatian Science Foundation; Israel-Italian collaborative project Network Cyber Security (NECST); Israel Science Foundation; Office of Naval Research (ONR); Japan Science Foundation; US-Israel Binational Science Foundation; US National Science Foundation (BSF-NSF); PHY-1505000 - NSF; CMMI-1125290 - NSF; CHE-1213217 - NSF; HDTRA1-14-1-0017 - Defense Threat Reduction Agency (DTRA); DE-AC07-05Id14517 - Department of Energy (DOE))Published versio

ABE for Circuits with Constant-Size Secret Keys and Adaptive Security

An important theme in research on attribute-based encryption (ABE) is minimizing the sizes of the secret keys and ciphertexts. In this work, we present two new ABE schemes with *constant-size* secret keys, that is, the key size is independent of the sizes of policies or attributes, and dependent only on the security parameter lambda. * We construct the first key-policy ABE scheme for circuits with constant-size secret keys, |sk_f|=poly(lambda), which concretely consist of only three group elements. The previous state-of-the-art construction by [Boneh et al., Eurocrypt \u2714] has key size polynomial in the maximum depth d of the policy circuits, |sk_f|=poly(d,lambda). Our new scheme removes this dependency of key size on d while keeping the ciphertext size the same, which grows linearly in the attribute length and polynomially in the maximal depth, |ct|=|x|poly(d,lambda). * We present the first ciphertext-policy ABE scheme for Boolean formulae that simultaneously has constant-size keys and succinct ciphertexts of size independent of the policy formulae, in particular, |sk_f|=poly(lambda) and |ct_x|=poly(|x|,lambda). Concretely, each secret key consists of only two group elements. Previous ciphertext-policy ABE schemes either have succinct ciphertexts but non constant-size keys [Agrawal--Yamada, Eurocrypt \u2720; Agrawal--Wichs--Yamada, TCC \u2720], or constant-size keys but large ciphertexts that grow with the policy size, as well as the attribute length. Our second construction is the first ABE scheme achieving *double succinctness*, where both keys and ciphertexts are smaller than the corresponding attributes and policies tied to them. Our constructions feature new ways of combining lattices with pairing groups for building ABE and are proven selectively secure based on LWE and in the generic (pairing) group model. We further show that when replacing the LWE assumption with its adaptive variant introduced in [Quach--Wee--Wichs FOCS \u2718] the constructions become adaptively secure

Spleen-Yang-deficiency patients with polycystic ovary syndrome have higher levels of visfatin

AbstractObjectiveTo study serum visfatin levels in women with polycystic ovary syndrome (PCOS) grouped by Traditional Chinese Medicine (TCM) patterns. To study the correlations of serum visfatin levels with homeostatic model assessment insulin resistance (HOMA-IR), fasting plasma glucose (FPG), fasting insulin (FINS), body mass index (BMI), testosterone (T), total cholesterol (TC), and triglycerides (TG).MethodsTwo hundred and twelve PCOS patients were placed into the following TCM pattern subgroups: Kidney-Yang deficiency (KYD) group, Spleen-Yang deficiency (SYD) group, stagnant Liver-Qi transforming into heat (SLQTH) group, and Kidney-Yin deficiency (KYIND) group. The correlations between serum visfatin levels and HOMA-IR, FPG, FINS, BMI, T, TC, and TG were analyzed.ResultsOf all patients with PCOS, there were 82 in the KYD group (38.6%), 67 in the SYD group (31.6%), 37 in the SLQTH group (17.5%), and 26 in the KYIND group (12.3%). Visfatin levels in all PCOS subgroups were higher than those in the control group (P<0.01 or P<0.05). Among these subgroups, the visfatin levels in the SYD group were significantly higher than those in the other three TCM pattern groups (P<0.05). There were no statistical differences among the remaining three pattern groups. The levels of BMI, FINS, HOMA-IR, T, and TG were significantly higher in all subgroups than those in the control group (P<0.05). There were no significant differences in FPG and TC between all PCOS subgroups and the control group (P>0.05). The SYD group had higher levels of FINS and HOMA-IR compared with the KYD, SLQTH, and KYIND groups (P<0.05). In all subgroups, after controlling for BMI, TG, TC, and age, visfatin was positively correlated with FINS (r= 0.197, P=0.015) and HOMA-IR (r=0.173, P=0.033), and was not correlated with T.ConclusionKYD and SYD patterns are most common in PCOS patients. Increased visfatin is a common pathophysiologic manifestation in PCOS patients. The SYD group had the highest levels of visfatin, and visfatin was positively correlated with FINS and HOMA-IR

ControlCom: Controllable Image Composition using Diffusion Model

Image composition targets at synthesizing a realistic composite image from a pair of foreground and background images. Recently, generative composition methods are built on large pretrained diffusion models to generate composite images, considering their great potential in image generation. However, they suffer from lack of controllability on foreground attributes and poor preservation of foreground identity. To address these challenges, we propose a controllable image composition method that unifies four tasks in one diffusion model: image blending, image harmonization, view synthesis, and generative composition. Meanwhile, we design a self-supervised training framework coupled with a tailored pipeline of training data preparation. Moreover, we propose a local enhancement module to enhance the foreground details in the diffusion model, improving the foreground fidelity of composite images. The proposed method is evaluated on both public benchmark and real-world data, which demonstrates that our method can generate more faithful and controllable composite images than existing approaches. The code and model will be available at https://github.com/bcmi/ControlCom-Image-Composition

Expression of an IRF-3 fusion protein and mouse estrogen receptor, inhibits hepatitis C viral replication in RIG-I-deficient Huh 7.5 cells

Interferon Regulatory Factor-3 (IRF-3) plays a central role in the induction of interferon (IFN) production and succeeding interferon-stimulated genes (ISG) expression en route for restraining hepatitis C virus (HCV) infection. Here, we established a stable Huh7.5-IRF3ER cell line expressing a fusion protein of IRF-3 and mouse estrogen receptor (ER) to examine IFN production and anti-HCV effects of IRF-3 in retinoic acid inducible-gene-I (RIG-I) deficient Huh 7.5 cells. Homodimerization of the IRF-3ER fusion protein was detected by Western blotting after treatment with the estrogen receptor agonist 4-hydrotamoxifen (4-HT) in Huh7.5-IRF3ER cells. Expression of IFN-α, IFN-β, and their inhibitory effects on HCV replication were demonstrated by real-time polymerase chain reaction (PCR). Peak expression of IFN-α and IFN-β was achieved 24-hours post 4-HT treatment, coinciding with the appearance of phosphorylated signal transducer and activator of transcription (STAT) proteins. Additionally, HCV viral replication declined in time-dependent fashion. In previous studies, a novel IFN-mediated pathway regulating expression of 1-8U and heterogeneous nuclear ribonucleoprotein M (hnRNP M) inhibited HCV internal ribosomal entry site (IRES)-dependent translation. When expression of ISGs such as 1-8U and hnRNP M were measured in 4-HT-treated Huh7.5-IRF3ER cells, both genes were positively regulated by activation of the IRF-3ER fusion protein. In conclusion, the anti-HCV effects of IRF-3ER homodimerization inhibited HCV RNA replication as well as HCV IRES-dependent translation in Huh7.5-IRF3ER cells. The results of this study indicate that IRF-3ER homodimerization is a key step to restore IFN expression in Huh7.5-IRF3ER cells and in achieving its anti-HCV effects

New Ways to Garble Arithmetic Circuits

The beautiful work of Applebaum, Ishai, and Kushilevitz [FOCS\u2711] initiated the study of arithmetic variants of Yao\u27s garbled circuits. An arithmetic garbling scheme is an efficient transformation that converts an arithmetic circuit $C: \mathcal{R}^n \rightarrow \mathcal{R}^m$ over a ring $\mathcal{R}$ into a garbled circuit $\widehat C$ and $n$ affine functions $L_i$ for $i \in [n]$, such that $\widehat C$ and $L_i(x_i)$ reveals only the output $C(x)$ and no other information of $x$. AIK presented the first arithmetic garbling scheme supporting computation over integers from a bounded (possibly exponentially large) range, based on Learning With Errors (LWE). In contrast, converting $C$ into a Boolean circuit and applying Yao\u27s garbled circuit treats the inputs as bit strings instead of ring elements, and hence is not arithmetic . In this work, we present new ways to garble arithmetic circuits, which improve the state-of-the-art on efficiency, modularity, and functionality. To measure efficiency, we define the rate of a garbling scheme as the maximal ratio between the bit-length of the garbled circuit $|\widehat C|$ and that of the computation tableau $|C|\ell$ in the clear, where $\ell$ is the bit length of wire values (e.g., Yao\u27s garbled circuit has rate $O(\lambda)$). $\bullet$ We present the first constant-rate arithmetic garbled circuit for computation over large integers based on the Decisional Composite Residuosity (DCR) assumption, significantly improving the efficiency of the schemes of Applebaum, Ishai, and Kushilevitz. $\bullet$ We construct an arithmetic garbling scheme for modular computation over $\mathcal{R} = \mathbb{Z}_p$ for any integer modulus $p$, based on either DCR or LWE. The DCR-based instantiation achieves rate $O(\lambda)$ for large $p$. Furthermore, our construction is modular and makes black-box use of the underlying ring and a simple key extension gadget. $\bullet$ We describe a variant of the first scheme supporting arithmetic circuits over bounded integers that are augmented with Boolean computation (e.g., truncation of an integer value, and comparison between two values), while keeping the constant rate when garbling the arithmetic part. To the best of our knowledge, constant-rate (Boolean or arithmetic) garbling was only achieved before using the powerful primitive of indistinguishability obfuscation, or for restricted circuits with small depth

College students' cyberloafing and the sense of meaning of life: The mediating role of state anxiety and the moderating role of psychological flexibility

BackgroundWith the gradual penetration of network media into various fields of people's life, the relationship between network behavior and the sense of meaning of life is bound to be closer and closer. The purpose of this study is to explore the mediating role of state anxiety between cyber loafing and the sense of meaning of life, and the moderating role of psychological flexibility in this mediating relationship.MethodologyWith 964 undergraduates recruited as subjects three-wave-time-lagged quantitative research design was conducted in China. All participants were required to complete a self-reported electronic questionnaire. Then, the mediating mechanism and moderating effect were explored with utilization of SPSS25.0.ResultsThe results showed that cyberloafing had significant negative correlation with the sense of meaning of life. Our analysis testing the mediating effect showed that state anxiety partially mediated the relationship between cyberloafing and the sense of meaning of life (indirect effect = −0.05, p &lt; 0.01,), while the mediating effect was 31.25% of the total effect. Our analysis testing the moderating effect showed that psychological flexibility significantly moderated the relationship between cyberloafing and state anxiety (interaction effect = −0.26, p &lt; 0.01). And our analysis testing the moderated mediating effect showed that psychological flexibility played a moderating role in the mediating effect of state anxiety.ConclusionBased on the findings of this study, college students' cyberloafing negatively affects their sense of meaning of life. Therefore, appropriate measures should be taken to supervise and restrict college students' Internet use and provide them with corresponding guidance; certain psychological adjustment measures should also be taken when necessary to help college students with low psychological flexibility in reducing their state anxiety and improving their sense of meaning of life

DiffUTE: Universal Text Editing Diffusion Model

Diffusion model based language-guided image editing has achieved great success recently. However, existing state-of-the-art diffusion models struggle with rendering correct text and text style during generation. To tackle this problem, we propose a universal self-supervised text editing diffusion model (DiffUTE), which aims to replace or modify words in the source image with another one while maintaining its realistic appearance. Specifically, we build our model on a diffusion model and carefully modify the network structure to enable the model for drawing multilingual characters with the help of glyph and position information. Moreover, we design a self-supervised learning framework to leverage large amounts of web data to improve the representation ability of the model. Experimental results show that our method achieves an impressive performance and enables controllable editing on in-the-wild images with high fidelity. Our code will be avaliable in \url{https://github.com/chenhaoxing/DiffUTE}

Cortisol dysregulation in anxiety infertile women and the influence on IVF treatment outcome

IntroductionDysregulation of the stress-regulatory hormone cortisol is associated with anxiety, but its potential impact on infertile women and in vitro fertilization (IVF) treatment remains unclear. This prospective cross-sectional study aimed at evaluating the dysregulation of cortisol and its correlation to anxiety in infertile women. The influence of stress on IVF outcomes was also investigated.MethodsA point-of-care test was used for the measurement of morning serum cortisol in 110 infertile women and 112 age-matching healthy individuals. A Self-Rating Anxiety Scale (SAS) was used for the anxiety assessment of infertile women, and 109 of them underwent IVF treatment starting with the GnRH-antagonist protocol. If clinical pregnancy was not achieved, more IVF cycles were conducted with adjusted protocols until the patients got pregnant or gave up.ResultsHigher morning serum cortisol level was identified for infertile patients, especially for the elder. Women with no anxiety showed significant differences in cortisol levels, monthly income, and BMI compared with those with severe anxiety. A strong correlation was found between the morning cortisol level and the SAS score. When the cutoff value is 22.25 μg/dL, cortisol concentration could predict the onset of anxiety with high accuracy (95.45%) among infertile women. After IVF treatments, women with high SAS scores (&gt;50) or cortisol levels (&gt;22.25 μg/dL) demonstrated a lower rate of pregnancy (8.0%-10.3%) and more IVF cycles, although the impact of anxiety was not affirmative.ConclusionHypersecretion of cortisol related to anxiety was prevalent among infertile women, but the influence of anxiety on multi-cycle IVF treatment was not affirmative due to the complicated treatment procedures. This study suggested that the assessment of psychological disorders and stress hormone dysregulation should not be overlooked. An anxiety questionnaire and rapid cortisol test might be included in the treatment protocol to provide better medical care

”Vi själva är det viktigaste verktyget för att göra utomhusundervisning möjlig.” : En kvalitativ studie om förskollärares upplevelser och uppfattningar om utomhusundervisning

Syftet med den föreliggande studien är att med utgångspunkt i förskollärares upplevelser och uppfattningar om utomhusundervisning, undersöka och belysa olika faktorer som kan påverka genomförandet av utomhusundervisning i den dagliga förskoleverksamheten och på så sätt påverkar barns möjligheter till lärande. Empirin samlas kvalitativt in från sex förskollärare genom online semistrukturerade intervjuer via digital plattform Zoom eller Teams. Med tematisk analys som analysmetod identifieras centrala teman av analytisk vikt och analyseras med hjälp av teoretiska begrepp inom ramfaktorteorin. I studien framkommer det flera ramfaktorer som kan påverka förskollärares arbete i utomhusundervisning, inklusive barnens intresse och nyfikenhet, förskollärarens kunskap, kompetens och attityd, barngruppens storlek, bemanning av personal, material för utomhusundervisning, storlek och utformning av förskolegården, förskolans lokal, planeringstid och ekonomi. De flesta hindrande ramfaktorer, såsom bristande materiella resurser, ogynnsam utformning av förskolegården eller barnens minskade intresse, kan kompenseras av förskolläraren genom sin kunskap, kompetens och positiv attityd. Slutsatser som kan dras från studien är att förskollärarens kunskap, kompetens och positiva attityd kring utomhusundervisning spelar den mest betydande rollen för att möjliggöra utomhusundervisning. Samtidigt med förskolans ekonomiska stöd som i hög grad möjliggör förutsättningar för andra ramfaktorer, skapas mer fördelaktiga förutsättningar för förskollärares arbete i utomhusundervisning. Detta främjar i sin tur ökad mångfald och kvalitet både i planeringen och genomförandet av utomhusundervisning, vilket ger gynnsamma möjligheter för barns lärande. Dessutom visar studien att utomhusundervisning och inomhusundervisning erbjuder olika värdefulla möjligheter för barns lärande. Därmed kommer vi också fram till att förskollärare bör kombinera båda undervisningsformerna för att främja barns lärande och möta olika barns behov.